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HBOT turns off your pro-inflammatory genes and turns on your anti-inflammatory genes.

“At 40 and 60 sessions, HBOT lengthens your telomeres—the end caps of your DNA that protect it from damage. You’re literally slowing aging.” — Nichole “Coco” Wolf, FNP, Coco Functional Wellness

Nichole Wolf returns—this time certified in hyperbaric oxygen therapy medicine—to break down a tool that most people associate only with burn victims and scuba divers. Turns out, HBOT (or HBOT) is one of the most powerful interventions for inflammation, healing, and longevity available today.

Here’s the mechanism: HBOT places you under increased atmospheric pressure, which pushes oxygen out of your red blood cells and into your plasma—saturating every cell in your body. Your mitochondria use that oxygen to make ATP (energy). And in the process, HBOT turns off pro-inflammatory genes and turns on anti-inflammatory genes. The result is dramatic reductions in inflammatory load, faster tissue regeneration, and healing across systems—wound repair, nerve regeneration, blood vessel growth, brain recovery from concussion and stroke.

Nichole addresses a longstanding debate: 1.3 atmospheres (soft chambers) vs 2.0 atmospheres (hard chambers). For years, 1.3 was dismissed as a “sham.” But research out of the University of Miami compared the two and found they each turn off different inflammatory markers—and some overlap. Both are effective. Alternating between them, when possible, may be optimal.

She also explains the protocol: at minimum, three sessions per week, no more than two days off in a row, with 20-minute sessions at whatever atmosphere is appropriate. And here’s the longevity headline—at 40 to 60 sessions, research shows HBOT lengthens telomeres, the end caps of your DNA that protect it from damage. That’s slowing aging at the cellular level.

Use cases discussed: eczema and skin inflammation, pre- and post-surgical recovery, concussions, strokes, cancer adjunct therapy (above 2.0 atmospheres), sleep, brain fog, and mental clarity. Nichole also touches on the value of pairing HBOT with genetic testing so you can target your specific inflammatory variants.

In this episode, you’ll learn:

• What hyperbaric oxygen therapy is and how it pushes oxygen into plasma and every cell in your body
• How HBOT turns off pro-inflammatory genes and turns on anti-inflammatory genes at the cellular level
• The difference between soft chambers (1.3 ATA) and hard chambers (2.0 ATA)—and why both are effective
• Why 40–60 sessions may lengthen telomeres and slow aging at the cellular level
• Use cases: eczema, surgical recovery, concussions, strokes, sleep, brain fog, cancer adjunct therapy
• The recommended protocol: 3+ sessions per week, no more than 2 days off, 20-minute sessions
• Why pairing HBOT with genetic testing helps you target your specific inflammatory variants

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